Rare but real: Unusual manifestations of hepatitis A

Hepatitis A is usually a self-limiting infection in children, commonly presenting with jaundice. However, rare extra-hepatic manifestations may complicate the course, including cardiac and pancreatic involvement. We report two paediatric cases of hepatitis A virus (HAV) infection with such atypical presentations. A 6-year-old boy presented with lethargy, vomiting, and bradycardia; an electrocardiogram revealed complete heart block progressing to Mobitz type I block, with bilateral pleural effusion. Also, a 10-year-old boy presented with acute abdominal pain and was found to have elevated pancreatic enzymes and imaging findings consistent with pancreatitis. Both improved with conservative management. These cases highlight the importance of recognising unusual systemic complications of HAV. They also reinforce the urgent need to integrate hepatitis A vaccination into the national immunisation schedule in India.

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Publication Details

Journal
Tropical Doctor
Published
2025-10-28
DOI
https://doi.org/10.1177/00494755251389746
Primary Topic
Hepatitis Viruses Studies and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00
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article

Rare but real: Unusual manifestations of hepatitis A

Mukta Mantan, Akanksha Mahajan, Shubham Bansal
Tropical Doctor
Hepatitis Viruses Studies and Epidemiology
article

Rare but real: Unusual manifestations of hepatitis A

Mukta Mantan, Akanksha Mahajan, Shubham Bansal
article en

Abstract

Hepatitis A is usually a self-limiting infection in children, commonly presenting with jaundice. However, rare extra-hepatic manifestations may complicate the course, including cardiac and pancreatic involvement. We report two paediatric cases of hepatitis A virus (HAV) infection with such atypical presentations. A 6-year-old boy presented with lethargy, vomiting, and bradycardia; an electrocardiogram revealed complete heart block progressing to Mobitz type I block, with bilateral pleural effusion. Also, a 10-year-old boy presented with acute abdominal pain and was found to have elevated pancreatic enzymes and imaging findings consistent with pancreatitis. Both improved with conservative management. These cases highlight the importance of recognising unusual systemic complications of HAV. They also reinforce the urgent need to integrate hepatitis A vaccination into the national immunisation schedule in India.

Tropical DoctorVol. 56(1)
Maulana Azad Medical College (IN)
Openalex Percentile: Top 59%
Hepatitis Viruses Studies and Epidemiology
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Rare but real: Unusual manifestations of hepatitis A — Mukta Mantan, Akanksha Mahajan, et al. · Tropical Doctor (2025) | TGRS Research Map | TGRS