Transcriptional and neuroprotective effects of hexokinase-2 inhibitors administered after stroke
These findings confirm an essential role for glycolysis in post-stroke, pro-inflammatory microglial activation. Selective HK2 inhibitors provide a clinically applicable approach for suppressing microglial activation and thereby improving outcomes after stroke.
Authors
- Gӧkhan Uruk (ORCID: https://orcid.org/0000-0002-8706-9443)
- Wenhan Chang (ORCID: https://orcid.org/0000-0001-6583-7176)
- Raymond A. Swanson (ORCID: https://orcid.org/0000-0002-3664-5359)
- Ebony Mocanu (ORCID: https://orcid.org/0000-0002-3955-3046)
- Sona Asatryan (ORCID: https://orcid.org/0000-0002-4325-3329)
- Chia‐Ling Tu (ORCID: https://orcid.org/0000-0002-7323-7733)
- Kajsa Arkelius (ORCID: https://orcid.org/0000-0003-1346-1909)
- Seok Joon Won (ORCID: https://orcid.org/0000-0002-8345-4037)
- Neel S. Singhal
- Kyung Soo Kim (ORCID: https://orcid.org/0000-0003-3501-1212)
- Nguyen Mai (ORCID: https://orcid.org/0000-0002-4738-9733)
- Khukheper Awakoaiye
- Devran Ogut
- Rachel Shon
Institutions
- San Francisco VA Medical Center (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s12974-025-03594-1
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68