Diagnostic Implications and Correlates of Plasma Adenosine Deaminase 2 Activity and <scp> <i>ADA2</i> </scp> Variants
We confirmed the utility of plasma ADA2 activity as a diagnostic assay and showed that the inflammatory phenotype of DADA2 occurred in cases with residual activity. In vitro findings illustrate potential interactions of ADA2 variants to synergistically disrupt protein function.
Authors
- Archana Khan (ORCID: https://orcid.org/0000-0003-0842-2198)
- Michael S. Hershfield (ORCID: https://orcid.org/0000-0003-3589-8554)
- Roxane Labrosse (ORCID: https://orcid.org/0000-0003-3448-2098)
- Daniel L. Kastner (ORCID: https://orcid.org/0000-0001-7188-4550)
- Tiphanie P. Vogel (ORCID: https://orcid.org/0000-0002-0857-133X)
- GSRSNK Naidu (ORCID: https://orcid.org/0000-0002-9727-044X)
- Jorge Kalil (ORCID: https://orcid.org/0000-0001-8415-4274)
- Roshini S. Abraham (ORCID: https://orcid.org/0000-0001-8109-8502)
- Li Wearn Koh (ORCID: https://orcid.org/0000-0001-7087-8183)
- Olha Halyabar (ORCID: https://orcid.org/0000-0002-3117-173X)
- Andreea Ioan (ORCID: https://orcid.org/0000-0001-8628-3352)
- Kailey Brodeur
- T. Moussa (ORCID: https://orcid.org/0000-0002-4237-7629)
- Raju Khubchandani (ORCID: https://orcid.org/0000-0003-0294-119X)
- Katherine D. Nowicki (ORCID: https://orcid.org/0000-0001-9661-0783)
- R. Grant Rowe (ORCID: https://orcid.org/0000-0003-3620-2950)
- Rosemary Peterson (ORCID: https://orcid.org/0000-0002-0959-2343)
- Teresa K. Tarrant (ORCID: https://orcid.org/0000-0003-4067-5363)
- Leonardo Oliveira Mendonça (ORCID: https://orcid.org/0000-0001-7533-1937)
- Kaylee Dollerschell
- Chengappa Kavadichanda (ORCID: https://orcid.org/0000-0002-3643-3989)
- Samar Freschi Barros
- Benzeeta Pinto (ORCID: https://orcid.org/0000-0002-8433-9882)
- Seigo Okada (ORCID: https://orcid.org/0000-0002-9150-1913)
- Megan A. Cooper (ORCID: https://orcid.org/0000-0002-5696-172X)
- Casey A. Rimland (ORCID: https://orcid.org/0000-0002-5187-6921)
- Samuel Shang Ming Lee (ORCID: https://orcid.org/0000-0002-8034-7738)
- Taizo A. Nakano (ORCID: https://orcid.org/0000-0003-0389-2297)
- Alexis‐Virgil Cochino
- Andrew L. D. Hsu
- Peter A. Nigrović
- Akiko Shimamura
- Aman Sharma (ORCID: https://orcid.org/0000-0003-0813-1243)
- Yasmine El Chazli (ORCID: https://orcid.org/0000-0002-9849-2204)
- Clara Lin (ORCID: https://orcid.org/0000-0002-5840-875X)
- Pui Y. Lee (ORCID: https://orcid.org/0000-0002-5779-4193)
- Miriah Gillispie‐Taylor (ORCID: https://orcid.org/0000-0002-4823-7221)
- Walaa Shoman (ORCID: https://orcid.org/0000-0002-7763-1180)
- Megan M. Perron (ORCID: https://orcid.org/0000-0003-4330-9692)
- Fatma Dedeoğlu (ORCID: https://orcid.org/0000-0002-7516-0848)
- Carl Esperanzate
- Qing Zhou (ORCID: https://orcid.org/0000-0003-0290-1286)
- Manpreet Meyer (ORCID: https://orcid.org/0009-0004-5700-8529)
- Yue Jian
- Xiangwei Sun
- Eric S. Sobel (ORCID: https://orcid.org/0000-0003-3048-0589)
- Michael T. Lam (ORCID: https://orcid.org/0000-0002-9832-2395)
- Alicia Díaz Kuan
- Susan J. Kelly
- Evan E. Hsu
- Ivona Aksentijevich
- Courtney E LeSon
- Rachel Weng
- Musaab A. Alhezam
- Sodality Sutnga
Institutions
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- National Institutes of Health (US)
- UMass Memorial Health Care (US)
- Nationwide Children's Hospital (US)
- Harvard University (US)
- Carol Davila University of Medicine and Pharmacy (RO)
- University of Massachusetts Chan Medical School (US)
- Duke University (US)
- Yamaguchi University (JP)
- Baylor College of Medicine (US)
- Universidad Peruana Cayetano Heredia (PE)
- Washington University in St. Louis (US)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Sir Run Run Shaw Hospital (CN)
- Tan Tock Seng Hospital (SG)
- University of Florida (US)
- Jacksonville University (US)
- National Human Genome Research Institute (US)
- Children's Hospital Colorado (US)
- Dell Children's Medical Center of Central Texas (US)
- Center for Cancer and Blood Disorders (US)
- Institutul National pentru Sanatatea Mamei si Copilului "Alessandrescu-Rusescu" (RO)
- Durham VA Health Care System (US)
- St. John's National Academy of Health Sciences (IN)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- St.John's Medical College Hospital (IN)
- Texas Children's Hospital (US)
- Instituto do Coração (PT)
- Guangdong Provincial People's Hospital (CN)
- Hospital Base Guillermo Almenara Irigoyen (PE)
- SRCC Children’s Hospital (IN)
- Center for Rheumatology (US)
- UMass Memorial Medical Center (US)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
- Post Graduate Institute of Medical Education and Research (IN)
- Alexandria University (EG)
- University of Colorado Denver (US)
- Florida College (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1002/art.43412
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen
- Brigham and Women's Hospital
- Rheumatology Research Foundation
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases