Verbascoside Suppresses Epithelial–Mesenchymal Transition and Mitochondrial Biogenesis by Targeting Anti-senescence Signaling in Castration-resistant Prostate Cancer
Verbascoside attenuates CRPC progression by modulating EMT, alleviating oxidative damage, enhancing mitochondrial function, and inhibiting prosenescence signaling pathways. These findings highlight its therapeutic potential for targeting senescence-related mechanisms in aggressive prostate cancer and provide a basis for future CRPC management strategies.
Authors
- Mu-Chiao Tung
- Wei‐Lun Huang (ORCID: https://orcid.org/0000-0002-5503-9418)
- Sih-Han Chen
- C.-Y. Wang
- Hsing‐Chia Mai (ORCID: https://orcid.org/0000-0002-1352-6680)
- Yu-Lin Yang
- Richard C. Wu (ORCID: https://orcid.org/0000-0001-9925-9677)
- Pei‐Fang Hsieh
- Victor C. Lin (ORCID: https://orcid.org/0000-0003-0075-7014)
- Chun‐Hsien Wu (ORCID: https://orcid.org/0000-0003-2205-6403)
Institutions
- I-Shou University (TW)
Publication Details
- Journal
- Cancer Genomics & Proteomics
- Published
- 2025-10-28
- DOI
- https://doi.org/10.21873/cgp.20554
- Primary Topic
- Phytochemical Studies and Bioactivities
- Type
- article
- Field-Weighted Citation Impact
- 0.00