Differential Proteomic Analysis of DEN-induced Hepatocellular Carcinoma in Male and Female Balb/c Mice Reveals Novel Sex-Specific Markers
In conclusion, our research provides sex-specific proteomic signatures in DEN-induced HCC. The identification of proteins associated with ribosomal subunits in males, and two previously unimplicated mitochondrial complex I proteins in females as prognostic markers suggests novel therapeutic targets that may inform sex-tailored treatment strategies for HCC.
Authors
- Javeria Iqbal (ORCID: https://orcid.org/0009-0004-1807-8567)
- Sana Mahmood
- Martin R. Larsen (ORCID: https://orcid.org/0000-0001-6203-0123)
- William Chi Shing Cho (ORCID: https://orcid.org/0000-0003-4174-4586)
- Rabia Sultan
- Muhammad Rizwan Alam (ORCID: https://orcid.org/0000-0002-1578-5723)
- Asma Gul (ORCID: https://orcid.org/0000-0003-0338-3134)
- Munazza Raza Mirza (ORCID: https://orcid.org/0000-0003-2102-2922)
- Muhammad Nawaz Tahir (ORCID: https://orcid.org/0000-0002-6815-9806)
- SALMMA SALAMAH SALIHAH
- Bareera Bibi
Institutions
- Griffith University (AU)
- International Islamic University, Islamabad (PK)
- Quaid-i-Azam University (PK)
- University of Southern Denmark (DK)
- University of Karachi (PK)
- Aarhus University (DK)
- International Center for Chemical and Biological Sciences (PK)
- Queen Elizabeth Hospital (CN)
- National University of Sciences and Technology (PK)
Publication Details
- Journal
- Cancer Genomics & Proteomics
- Published
- 2025-10-28
- DOI
- https://doi.org/10.21873/cgp.20540
- Citations
- 1
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81