SCAMP3 and EPS8 Cooperatively Regulate EGFR Signaling to Promote Enzalutamide Resistance and Metastatic Potential in Prostate Cancer
SCAMP3 and EPS8 cooperatively maintain EGFR stability and signaling in prostate cancer cells, playing a critical role in enzalutamide resistance and metastatic progression. Targeting the SCAMP3-EPS8-EGFR axis offers promising therapeutic opportunities for advanced prostate cancer.
Authors
- See‐Tong Pang (ORCID: https://orcid.org/0000-0002-2064-0828)
- Victor C. Lin (ORCID: https://orcid.org/0000-0003-4647-9902)
- Hai‐Qiang Mai (ORCID: https://orcid.org/0000-0002-9035-6814)
- Wei‐Lun Huang (ORCID: https://orcid.org/0000-0002-5503-9418)
- Sih-Han Chen
- Yu-Lin Yang
- Richard C. Wu (ORCID: https://orcid.org/0000-0001-9925-9677)
- Pei‐Fang Hsieh
- Chun‐Hsien Wu (ORCID: https://orcid.org/0000-0003-2205-6403)
Institutions
- Chung Hwa University of Medical Technology (TW)
- Chang Gung University of Science and Technology (TW)
- Chang Gung University (TW)
- Chang Gung Memorial Hospital (TW)
- E-Da Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
- I-Shou University (TW)
Publication Details
- Journal
- Cancer Genomics & Proteomics
- Published
- 2025-10-28
- DOI
- https://doi.org/10.21873/cgp.20549
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00