Incomplete Family History and Meeting Algorithmic Criteria for Genetic Evaluation of Hereditary Cancer
In this cross-sectional study, the magnitude of the association between incomplete family history documentation and identification of patients eligible for hereditary cancer genetic evaluation depended on whether data were missing randomly or systematically. These findings suggest that health care organizations implementing CDS algorithms should assess their specific missing data patterns and consider tailored approaches to handling incomplete family history information to ensure equitable identification of all patients who could benefit from genetic evaluation services.
Authors
- Kensaku Kawamoto (ORCID: https://orcid.org/0000-0003-4282-9338)
- Kimberly A. Kaphingst (ORCID: https://orcid.org/0000-0003-2668-9080)
- Daniel Chavez‐Yenter (ORCID: https://orcid.org/0000-0001-7764-4443)
- Rachelle Lorenz Chambers (ORCID: https://orcid.org/0000-0003-2478-8835)
- Meenakshi Sigireddi (ORCID: https://orcid.org/0000-0003-4448-0504)
- Richard L. Bradshaw (ORCID: https://orcid.org/0000-0001-7363-0327)
- Guilherme Del Fiol (ORCID: https://orcid.org/0000-0001-9954-6799)
- Wendy K. Kohlmann (ORCID: https://orcid.org/0000-0002-9134-9640)
- Melody S. Goodman (ORCID: https://orcid.org/0000-0001-8932-624X)
- Jemar R. Bather (ORCID: https://orcid.org/0000-0002-0285-3678)
- Rachel Monahan (ORCID: https://orcid.org/0000-0003-1000-2790)
- Adrian Harris (ORCID: https://orcid.org/0009-0008-1124-9190)
Institutions
- University of Utah (US)
- Spencer Foundation (US)
- Huntsman Cancer Institute (US)
- NYU Langone Health (US)
- Durham VA Medical Center (US)
- New York University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.39870
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- National Cancer Institute