Real‐world effectiveness and safety of sacituzumab govitecan in patients with metastatic or unresectable locally advanced triple‐negative breast cancer: A multicenter study by the Turkish Oncology Group
Sacituzumab govitecan (SG) is an antibody-drug conjugate approved for metastatic or unresectable locally advanced triple-negative breast cancer (mTNBC) after at least two prior systemic therapies, yet real-world evidence remains limited. We conducted a retrospective, multicenter study including 285 patients with unresectable locally advanced or metastatic TNBC treated with SG across 52 oncology centers in Turkey. Median progression-free and overall survival were 5.4 months (95% confidence interval [CI], 4.6-6.2) and 12.2 months (95% CI, 10.5-13.9), respectively, with a 12-month overall survival rate of 49.2%. The objective response rate and disease control rate in evaluable patients were 36.8% and 63.9%. Grades 3-4 adverse events, mainly neutropenia, occurred in 44.2% of patients. Dose reductions were needed in 20% of cases; no treatment-related deaths were reported. Our large real-world cohort reinforces the effectiveness and manageable safety profile of SG, mirroring pivotal trials, and highlights its value as a therapeutic option in diverse and heavily pretreated mTNBC populations.
Authors
- Gökhan Öztürk (ORCID: https://orcid.org/0000-0002-9390-4628)
- Ali Aytac
- Bilgin Demir (ORCID: https://orcid.org/0000-0003-4380-9419)
- Fatma Keskin Uzundere
- Nargız Majidova (ORCID: https://orcid.org/0000-0002-2575-5819)
- Eda Tanrıkulu Şimşek
- Pınar Gürsoy (ORCID: https://orcid.org/0000-0003-1392-6753)
- Safa Can Efil (ORCID: https://orcid.org/0000-0001-9586-2858)
- Oğuzcan Kınıkoğlu (ORCID: https://orcid.org/0000-0001-5983-3291)
- Mustafa Ersoy (ORCID: https://orcid.org/0000-0003-1815-5804)
- İlhan Hacıbekiroğlu (ORCID: https://orcid.org/0000-0002-0333-7405)
- Taha Koray Şahin (ORCID: https://orcid.org/0000-0002-3590-0426)
- Alberto Terzi (ORCID: https://orcid.org/0000-0002-2272-0389)
- Burcu Belen
- Ali Kaan Güren (ORCID: https://orcid.org/0000-0002-3562-5006)
- Selami Bayram (ORCID: https://orcid.org/0000-0002-0930-5025)
- Ali Kaya (ORCID: https://orcid.org/0000-0001-7182-6641)
- Murad Guliyev (ORCID: https://orcid.org/0000-0002-2981-8098)
- Teyfik Demi̇r (ORCID: https://orcid.org/0000-0001-6352-8302)
- Teoman Şakalar (ORCID: https://orcid.org/0000-0003-2749-9414)
- Mehmet Alı Nahıt Şendur (ORCID: https://orcid.org/0000-0001-7021-6139)
- Sercan Aksoy (ORCID: https://orcid.org/0000-0003-4984-1049)
- Tuğba Akın Telli (ORCID: https://orcid.org/0000-0001-6535-6030)
- Esmanur Kaplan
- Ferit Aslan (ORCID: https://orcid.org/0000-0002-9153-6921)
- Elvina Almuradova (ORCID: https://orcid.org/0000-0002-5551-7731)
- Hasan Çağrı Yıldırım (ORCID: https://orcid.org/0000-0003-3060-377X)
- Emine Türkmen (ORCID: https://orcid.org/0000-0002-3356-5871)
- Mustafa Seyyar (ORCID: https://orcid.org/0000-0002-4841-7994)
- Fatma Paksoy Türköz
- Erdem Göker (ORCID: https://orcid.org/0000-0001-6180-713X)
- Ahmet Halil Sevinç (ORCID: https://orcid.org/0000-0003-2965-1782)
- Ali̇ İnal (ORCID: https://orcid.org/0000-0002-0690-2529)
- Alper Türkel (ORCID: https://orcid.org/0000-0001-5071-9679)
- Ahmet Fatih Oruç (ORCID: https://orcid.org/0009-0003-0923-5148)
- Yakup Düzköprü (ORCID: https://orcid.org/0000-0003-2314-5870)
- İrem Uğurlu (ORCID: https://orcid.org/0000-0001-6325-6175)
- Ferhat Ekinci (ORCID: https://orcid.org/0000-0002-9317-942X)
- Devrim Çabuk (ORCID: https://orcid.org/0000-0002-7871-6311)
- Hamit Bal (ORCID: https://orcid.org/0009-0009-6747-8264)
- Ahmet Ünlü (ORCID: https://orcid.org/0000-0001-6654-3815)
- Melek Karakurt Eryılmaz (ORCID: https://orcid.org/0000-0003-2597-5931)
- Murat Karateke
- Oktay Demirkıran (ORCID: https://orcid.org/0000-0003-1319-9381)
- Umut Aydın (ORCID: https://orcid.org/0000-0003-4802-8793)
- Elif Şahin (ORCID: https://orcid.org/0000-0002-1976-3951)
- Ahmet Özveren (ORCID: https://orcid.org/0000-0002-6432-5432)
- Abdullah Sakin (ORCID: https://orcid.org/0000-0003-2538-8569)
- Yunus Emre Altıntaş (ORCID: https://orcid.org/0000-0002-0634-7350)
- Sait Kitaplı (ORCID: https://orcid.org/0000-0002-1143-1864)
- Barış Gezici
- Salih Tünbekici (ORCID: https://orcid.org/0000-0001-8804-7636)
- Özge Yalıcı (ORCID: https://orcid.org/0009-0002-0260-7511)
- Di̇lek Erdem (ORCID: https://orcid.org/0000-0001-6495-6712)
- Deniz Can Güven (ORCID: https://orcid.org/0000-0002-6924-9467)
- Banu Öztürk
- Nilgün Yıldırım (ORCID: https://orcid.org/0000-0001-8198-2605)
- Mutlu Doğan
- Gökhan Şahin (ORCID: https://orcid.org/0000-0003-1478-9383)
- Esra Aşık (ORCID: https://orcid.org/0000-0003-3030-2475)
- Fatma Akdağ Kahvecıoglu
- Tuğçe Kübra Güneş (ORCID: https://orcid.org/0000-0002-7917-2459)
- Nilüfer Avcı (ORCID: https://orcid.org/0000-0003-1094-5772)
- Atilla Yıldırım
- Sercan Ön (ORCID: https://orcid.org/0000-0003-1461-7485)
- Esra Asarkaya
- Alper Coşkun (ORCID: https://orcid.org/0000-0003-2444-6587)
- Taliha Guclu
- Ibrahim Tunbekici (ORCID: https://orcid.org/0009-0008-3943-7871)
- Enes Yeşilbaş (ORCID: https://orcid.org/0000-0002-0947-702X)
- Ufuk Camanlı (ORCID: https://orcid.org/0000-0003-4494-9309)
- Gamze Emin (ORCID: https://orcid.org/0000-0002-1549-7326)
- Erdem Kolemen
- İsmet Çulcuoğlu (ORCID: https://orcid.org/0000-0003-0333-5191)
- Oguz Altınok
- Yurdagül Danacı (ORCID: https://orcid.org/0009-0000-2414-8665)
Institutions
- Aksaray University (TR)
- Dicle University (TR)
- Trakya University (TR)
- Tekirdağ Namık Kemal University (TR)
- Bursa Uludağ Üni̇versi̇tesi̇ (TR)
- Izmir University (TR)
- Anadolu University (TR)
- Karadeniz Technical University (TR)
- Istanbul Bilim University (TR)
- Manisa Celal Bayar University (TR)
- Bursa Technical University (TR)
- Dokuz Eylül University (TR)
- Inonu University (TR)
- Ondokuz Mayıs University (TR)
- Kütahya Dumlupınar Üniversitesi (TR)
- Istanbul Medipol University (TR)
- Ege University (TR)
- Fatih University Medical Faculty Hospital (TR)
- Memorial Ankara Hospital (TR)
- Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi (TR)
- Necmettin Erbakan University (TR)
- Ankara Onkoloji Eğitim ve Araştırma Hastanesi (TR)
- Antalya Eğitim ve Araştırma Hastanesi (TR)
- Ümraniye Eğitim ve Araştırma Hastanesi (TR)
- Istanbul University-Cerrahpaşa (TR)
- Medical Park Gaziantep Hospital (TR)
- Hacettepe University Hospital (TR)
- Sakarya Eğitim ve Araştırma Hastanesi (TR)
- Istinye University (TR)
- Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi (TR)
- Şanlıurfa Mehmet Akif İnan Eğitim ve Araştırma Hastanesi (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Istanbul Eye Hospital (TR)
- Kent Hastanesi (TR)
- Antalya IVF (TR)
- Maltepe University (TR)
- Kahramanmaraş Sütçü İmam University (TR)
- Pamukkale University (TR)
- Mersin Üniversitesi (TR)
- Kocaeli Üniversitesi (TR)
- Cukurova University (TR)
- Marmara University (TR)
- Adnan Menderes University (TR)
- Muğla University (TR)
Publication Details
- Journal
- International Journal of Cancer
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1002/ijc.70213
- Citations
- 1
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05