Assessing the Independent and Combined Effects of Hyperosmolarity and Inflammatory Stress on Human Corneal Epithelial Cells
This study demonstrates for the first time the combined effect of hyperosmolarity and inflammation that disrupts corneal epithelial homeostasis in vitro, leading to increased oxidative stress by expressing HMOX1, COX2, TonEBP, HIF1, and inflammatory cytokine production. These findings provide further insights into the pathophysiology of DED and support the development of an in vitro model that mitigates hyperosmolar and inflammatory stress-induced epithelial defects.
Authors
- Sayan Basu (ORCID: https://orcid.org/0000-0001-5030-5003)
- Pragnya Rao Donthineni (ORCID: https://orcid.org/0000-0002-7624-2239)
- M. A. Rehman Siddiqui (ORCID: https://orcid.org/0000-0001-5100-3189)
- Swati Singh (ORCID: https://orcid.org/0000-0001-7420-9438)
- Deeksha Prasad (ORCID: https://orcid.org/0009-0002-3602-594X)
- Vivek Singh (ORCID: https://orcid.org/0000-0003-0805-1147)
- Mehraj U Din Dar (ORCID: https://orcid.org/0000-0001-9430-8468)
- Rohini Sonar
Institutions
- Manipal Academy of Higher Education (IN)
- L V Prasad Eye Institute (IN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1167/iovs.66.13.47
- Citations
- 3
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 5.64