Dualistic Role of MITF in Uveal Melanoma: Defining Two Distinct Cellular Subpopulations With Prognostic and Therapeutic Implications
MITF delineates two UM subpopulations: (1) MITF-low tumors-slow proliferators with high invasive potential and inflammatory phenotype, and (2) MITF-high tumors-rapidly dividing cells with lower invasiveness and immunosuppressive properties. These findings suggest potential therapeutic strategies, including MITF re-induction for MITF-low tumors and dTYMK/PARP1 inhibitors for MITF-high UM.
Authors
- Bożena Romanowska-Dixon (ORCID: https://orcid.org/0000-0003-4251-2533)
- Justyna Pilch (ORCID: https://orcid.org/0000-0001-8351-9622)
- Anna Markiewicz (ORCID: https://orcid.org/0000-0003-0943-6575)
- Mai P. Hoang (ORCID: https://orcid.org/0000-0002-1406-7981)
- Antonina Joanna Mazur (ORCID: https://orcid.org/0000-0002-7561-9030)
- Mateusz Krzyziński (ORCID: https://orcid.org/0000-0001-6143-488X)
- Przemysław Biecek (ORCID: https://orcid.org/0000-0001-8423-1823)
- Piotr Donizy (ORCID: https://orcid.org/0000-0002-8729-6216)
Institutions
- Warsaw University of Technology (PL)
- Jagiellonian University (PL)
- Harvard University (US)
- University of Wrocław (PL)
- Wroclaw Medical University (PL)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1167/iovs.66.13.45
- Citations
- 1
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71