Temporal Analysis of Tear Fluid Proteome Reveals Critical Corneal Repair Events After Photorefractive Surgery
Time-stamped, tear-accessible biomarker panels emerge from this analysis: early-injury (TGFBI, lumican/keratocan, fibrinogen/complement), sustained (A2M, haptoglobin, OLFML3), and late-remodeling/epithelial (SERPINA3, MMP7, THBS1, MUC5B, CXCL17), with complementary intracellular markers (AQP5/NHERF1/ANO1). These candidates may support perioperative monitoring, risk stratification (delayed closure, stromal haze), and phase-adapted therapy after PRK, warranting prospective clinical validation.
Authors
- Vincent Daïen (ORCID: https://orcid.org/0000-0001-5675-0861)
- Frédéric Michon (ORCID: https://orcid.org/0000-0003-4305-305X)
- Jana Kindermans (ORCID: https://orcid.org/0000-0001-6218-7753)
- Nadège Feret
- Christophe Hirtz (ORCID: https://orcid.org/0000-0002-7313-0629)
- Jérôme Vialaret (ORCID: https://orcid.org/0000-0002-3730-2366)
- Karine Loulier (ORCID: https://orcid.org/0000-0001-6216-2708)
- Laura Fichter
- Hannah Crowdy
- Solene ter Schiphorst
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Montpellier (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Hôpital Gui de Chauliac (FR)
- Institute for Neurosciences of Montpellier (FR)
- Ingham Institute (AU)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1167/iovs.66.13.49
- Citations
- 2
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Centre Hospitalier Régional Universitaire de Montpellier
- Université de Montpellier
- Région Occitanie Pyrénées-Méditerranée