Genetics of Cholesterol and Coronary Disease Risk across Six Global Ancestries
Our findings demonstrated a consistent association between LDL-C and CAD risk across diverse ancestry groups that are often poorly represented in clinical trials, although effect magnitudes varied. (Funded by the National Institutes of Health and others.).
Authors
- Qiuli Chen (ORCID: https://orcid.org/0000-0001-8531-6175)
- Minxian Wang (ORCID: https://orcid.org/0000-0002-3753-508X)
- Satoshi Koyama (ORCID: https://orcid.org/0000-0002-9286-0360)
- David A. van Heel (ORCID: https://orcid.org/0000-0002-0637-2265)
- Anika Misra (ORCID: https://orcid.org/0009-0002-6217-0948)
- Ko Ito (ORCID: https://orcid.org/0000-0003-3879-1963)
- Sarah Urbut (ORCID: https://orcid.org/0000-0002-1135-9647)
- Sarah Finer (ORCID: https://orcid.org/0000-0002-2684-4653)
- Akl C. Fahed (ORCID: https://orcid.org/0000-0002-4849-6389)
- Fowzan Sami Alkuraya (ORCID: https://orcid.org/0000-0003-4158-341X)
- Whitney Hornsby (ORCID: https://orcid.org/0000-0002-0672-0338)
- Yang Sui
- Gina M. Peloso
- Pradeep Natarajan
Institutions
- Broad Institute (US)
- Boston University (US)
- Alfaisal University (SA)
- Queen Mary University of London (GB)
- Chinese Academy of Sciences (CN)
- King Faisal Specialist Hospital & Research Centre (SA)
- Beijing Institute of Genomics (CN)
- Massachusetts General Hospital (US)
- RIKEN Center for Integrative Medical Sciences (JP)
- Shanghai Center For Bioinformation Technology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- NEJM Evidence
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1056/evidoa2500105
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.63