Cardiac Effects of Dapagliflozin in People with Chronic Kidney Disease
In a heterogeneous population of patients with chronic kidney disease, dapagliflozin significantly reduced left ventricular mass index compared with placebo. These findings provide mechanistic insights into the early treatment benefits of SGLT2 inhibitors seen previously in chronic kidney disease. Further research is needed to replicate and further define these early treatment benefits. (Funded by the Danish Cardiovascular Academy and Novo Nordisk Foundation; ClinicalTrials.gov number, NCT05359263.).
Authors
- Nino Emanuel Landler (ORCID: https://orcid.org/0000-0001-5255-787X)
- Katja Vu Bartholdy
- Iain Bressendorff (ORCID: https://orcid.org/0000-0003-2711-4799)
- Bo Feldt‐Rasmussen (ORCID: https://orcid.org/0000-0002-8267-3027)
- Frederik Persson (ORCID: https://orcid.org/0000-0001-6242-6638)
- Caroline Espersen (ORCID: https://orcid.org/0000-0003-2879-8862)
- Morten Sengeløv (ORCID: https://orcid.org/0000-0002-2139-8068)
- Lise Witten Davodian
- Camilla Ikast Ottosen (ORCID: https://orcid.org/0000-0002-8446-6216)
- Anne Marie Reimer Jensen (ORCID: https://orcid.org/0000-0003-3272-636X)
- Kristoffer Grundtvig Skaarup (ORCID: https://orcid.org/0000-0002-2690-7511)
- Adam Cadovius Femerling Langhoff (ORCID: https://orcid.org/0000-0002-6073-2938)
- Morten Schou (ORCID: https://orcid.org/0000-0002-4271-2466)
- Lars Køber (ORCID: https://orcid.org/0000-0002-6635-1466)
- Mats Christian Højbjerg Lassen (ORCID: https://orcid.org/0000-0002-2255-582X)
- Jacob Christensen (ORCID: https://orcid.org/0000-0002-4231-0299)
- Filip Soeskov Davidovski (ORCID: https://orcid.org/0000-0002-6642-416X)
- Daniel Modin (ORCID: https://orcid.org/0000-0002-7566-0519)
- Ditte Hansen (ORCID: https://orcid.org/0000-0003-4929-7901)
- Maria Dons (ORCID: https://orcid.org/0000-0003-3506-6862)
- Niklas Dyrby Johansen (ORCID: https://orcid.org/0000-0001-6959-3236)
- Tor Biering‐Sørensen (ORCID: https://orcid.org/0000-0003-4209-2778)
- Peter R Rossing (ORCID: https://orcid.org/0000-0002-1531-4294)
- Richard Haynes (ORCID: https://orcid.org/0000-0002-1179-0023)
- Julie Borchsenius
- J. Steen Jensen (ORCID: https://orcid.org/0000-0003-2821-9947)
- Scott D Solomon
- Muthiah Vaduganathan
- Faı̈ez Zannad (ORCID: https://orcid.org/0000-0001-7456-1570)
Institutions
- University of Copenhagen (DK)
- Brigham and Women's Hospital (US)
- Steno Diabetes Centers (DK)
- Harvard University (US)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- University of Oxford (GB)
- Centre d’Investigation Clinique Innovation Technologique de Nancy (FR)
- Université de Lorraine (FR)
Publication Details
- Journal
- NEJM Evidence
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1056/evidoa2500158
- Citations
- 3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.88