Indomethacin Fails to Increase Intestinal Permeability in Healthy Volunteers
Our findings suggest that the expected increase in intestinal permeability after indomethacin administration may not be consistently observed in healthy volunteers. These results highlight the need to carefully consider the reproducibility and sensitivity of this model in future clinical studies aiming to investigate gut barrier function.
Authors
- Michael Camilleri (ORCID: https://orcid.org/0000-0001-6472-7514)
- Saam Dilmaghani
- David Yi Yang (ORCID: https://orcid.org/0000-0002-0721-0647)
- Michael Ryks
- Irene Busciglio
- François Montestruc (ORCID: https://orcid.org/0000-0002-1151-6630)
- Stéphanie Perot
- Dounia Houamel
- Camille Lupianez‐Merly
- Monique Ferber
- Paula Carlson
Institutions
- Mayo Clinic (US)
- Sanofi (France) (FR)
- Mayo Clinic in Florida (US)
- Biocodex (France) (FR)
Publication Details
- Journal
- Clinical and Translational Gastroenterology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.14309/ctg.0000000000000944
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00