High-Dose Stereotactic Re-Irradiation of Recurrent High-Grade Gliomas: Clinical Outcome and Experience with AI-Based Target Volume Simulation
High-dose SRS is a feasible salvage treatment for small-volume recurrent high-grade gliomas, achieving local control and survival outcomes comparable to other re-irradiation strategies. IDH mutation, smaller tumor volume, and lomustine therapy were associated with improved survival. RN occurred frequently, particularly in periventricular lesions. AI-based tumor segmentation showed promise in well-defined satellite recurrences, but remains limited in cavity-adjacent lesions, underlining the need for expert review and <sup>18</sup>FET-PET imaging.
Authors
- Daniel Zips (ORCID: https://orcid.org/0000-0001-5779-9675)
- Peter Vajkoczy (ORCID: https://orcid.org/0000-0003-4350-392X)
- Larissa S. Kilian
- Kerstin Rubarth (ORCID: https://orcid.org/0000-0002-6174-6346)
- Martin Misch (ORCID: https://orcid.org/0000-0001-5283-5753)
- Franziska Loebel (ORCID: https://orcid.org/0000-0002-3986-9243)
- Carolin Senger (ORCID: https://orcid.org/0000-0001-7700-4657)
- Goda Kalinauskaitė (ORCID: https://orcid.org/0000-0003-3798-1546)
- Julia Onken (ORCID: https://orcid.org/0000-0002-2859-4395)
- Anton Früh (ORCID: https://orcid.org/0000-0002-2982-2046)
- Güliz Acker (ORCID: https://orcid.org/0000-0002-8946-6426)
- Anne Kluge (ORCID: https://orcid.org/0000-0001-7844-0426)
- Chiara Eitner
- Bohdan Bodnar
Institutions
- Zimmer Biomet (Germany) (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Cancers
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3390/cancers17213423
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63