PRDX5 Regulates Mitochondrial Function and Nuclear Spreading in Myogenesis and Acts With PRDX3 to Delay Muscle Aging
Our findings reveal a previously unidentified role of PRDX5 in coordinating mitochondrial function and nuclear positioning during myogenesis and muscle regeneration. The combined deficiency of PRDX3 and PRDX5 accelerates muscle aging by exacerbating oxidative stress and mitochondrial dysfunction, suggesting that enhancing their activity may be a promising therapeutic strategy to prevent sarcopenia and age-related muscle degeneration.
Authors
- Joonho Suh (ORCID: https://orcid.org/0000-0003-2438-0071)
- Hyun Ae Woo (ORCID: https://orcid.org/0000-0002-3483-1203)
- Max A. Tischfield (ORCID: https://orcid.org/0000-0002-1532-3975)
- Jung Eun Baik (ORCID: https://orcid.org/0000-0002-0471-8058)
- Wonn Shim
- Yun‐Sil Lee (ORCID: https://orcid.org/0000-0002-1228-0404)
- Je‐Hyun Eom
Institutions
- Rutgers, The State University of New Jersey (US)
- Ewha Womans University (KR)
- Seoul National University (KR)
- Dongguk University (KR)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1002/jcsm.70098
- Citations
- 1
- Primary Topic
- Redox biology and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.81