Cost-effectiveness analysis of metagenomic next-generation sequencing versus traditional bacterial cultures for postoperative central nervous system infections in critical care settings: a prospective pilot study
mNGS improves diagnostic efficiency and reduces antimicrobial expenditure for postoperative CNSIs in critical care, demonstrating favorable cost-effectiveness when considering clinical outcome gains.
Authors
- Linlin Zhang (ORCID: https://orcid.org/0000-0002-5960-4605)
- Yuqing Chen (ORCID: https://orcid.org/0000-0001-7857-3106)
- Ningyuan Xu
- Zhaoyi Xu (ORCID: https://orcid.org/0000-0001-9109-1670)
- Ying Tian (ORCID: https://orcid.org/0000-0001-7682-6907)
- Zhou Jian-xin
Institutions
- University of Kentucky (US)
- Beijing Tian Tan Hospital (CN)
- Beijing Anzhen Hospital (CN)
- Beijing Shijitan Hospital (CN)
- Beijing Information Science & Technology University (CN)
- University of Science and Technology Beijing (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fcimb.2025.1710412
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00