Targeting METTL16 attenuates mesangial cell viability and fibrosis in a high-glucose state by suppressing m6A modification and the expression of RAP1B
METTL16 knockdown attenuates cell viability and fibrosis by reducing m6A modification and the expression of RAP1B in high glucose-treated mesangial cells, suggesting the potential of METTL16 as a treatment target for DKD.
Authors
- Yanhong Luo (ORCID: https://orcid.org/0000-0002-2394-6339)
- Weixu Wang (ORCID: https://orcid.org/0000-0001-8482-539X)
Institutions
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- BMC Molecular and Cell Biology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s12860-025-00559-3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00