Heterogeneous origins and functions of lung mesenchymal stromal cells
Two different lung MSC subpopulations have been identified and characterized. These findings advance our understanding of the complexity of mesenchymal progenitors in lung injury repair and disease and may inform the development of effective stem cell-based therapies for pulmonary conditions.
Authors
- Matthew E. Thornton (ORCID: https://orcid.org/0000-0002-1083-2703)
- Dan-Yi Peng (ORCID: https://orcid.org/0009-0008-2836-2325)
- Satish K. Madala
- Brendan H. Grubbs (ORCID: https://orcid.org/0000-0002-1963-4922)
- Elizabeth P. Henske (ORCID: https://orcid.org/0000-0001-7978-6699)
- Ruili Yang (ORCID: https://orcid.org/0000-0002-3283-9893)
- Wei Shi (ORCID: https://orcid.org/0000-0001-6499-2473)
- Ke Cao (ORCID: https://orcid.org/0000-0002-0934-6468)
- Susan M. Majka (ORCID: https://orcid.org/0000-0002-1005-1552)
- Hui Chen (ORCID: https://orcid.org/0000-0001-6883-3752)
- Yongfeng Luo (ORCID: https://orcid.org/0000-0001-8765-0273)
Institutions
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- Children's Hospital of Los Angeles (US)
- Harvard University (US)
- National Jewish Health (US)
- University of Cincinnati (US)
- University of Cincinnati Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s13287-025-04716-5
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Southern California
- National Institutes of Health
- National Heart, Lung, and Blood Institute