FGF21 confers neuroprotection in Parkinson’s disease by activating the FGFR1-sirt1 pathway
FGF21 exerts multi-faceted protection in PD via the FGFR1-Sirt1 axis, including BBB repair, mitochondrial homeostasis restoration, microglial polarization towards M2, balancing autophagy and apoptosis, and promoting neuronal survival.
Authors
- Jianshe Wei (ORCID: https://orcid.org/0000-0002-3560-3392)
- Tingting Liu (ORCID: https://orcid.org/0000-0003-1420-1287)
Institutions
- Henan University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s11658-025-00807-6
- Citations
- 6
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- Henan University