Miro1 protects against brain injury after CPR in rats by enhancing the effect of BMSCs on mitochondrial homeostasis
These analyses revealed that BMSC transplantation has a dual protective effect by facilitating healthy mitochondrial transfer and promoting the autophagic degradation of damaged mitochondria, effectively enhancing hippocampal neuronal mitochondrial function following CA while reducing neuronal apoptosis, restoring neuronal function, and alleviating neuropathological damage. Moreover, Miro1 can enhance the efficiency of mitochondrial transfer and promote BMSC-mediated mitophagy induction, thereby optimizing the therapeutic effect of BMSCs.
Authors
- Xuyuan Ma
- Meng Zeng (ORCID: https://orcid.org/0009-0009-5605-6496)
- YanLiang Qu
- Qian Zhou (ORCID: https://orcid.org/0000-0002-2829-056X)
- Zhen Wang (ORCID: https://orcid.org/0009-0008-5083-1853)
- Maozheng Shen (ORCID: https://orcid.org/0009-0008-3750-679X)
- Jiayu Hu (ORCID: https://orcid.org/0000-0003-2423-9465)
- Xiang Zhou (ORCID: https://orcid.org/0000-0001-9635-8741)
- Jie Zhu (ORCID: https://orcid.org/0000-0002-9921-6164)
- Mengda Xu
Institutions
- Hubei University of Medicine (CN)
- Wuhan University (CN)
- People's Liberation Army 401 Hospital (CN)
- Zhongnan Hospital of Wuhan University (CN)
- PLA Navy General Hospital (CN)
- Central Hospital of Wuhan (CN)
- Wuhan General Hospital of Guangzhou (CN)
- General Hospital of Central Theater Command
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s13287-025-04724-5
- Citations
- 1
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province