Single-cell landscape of mouse lungs exposed to intermittent hypoxia
This study identifies SP1 as a master regulator of IH-induced pulmonary remodeling through coordinated control of fibrotic, inflammatory, and vascular pathways. These findings provide mechanistic insights into OSAHS-related complications and highlight SP1 inhibition as a potential therapeutic strategy for hypoxia-induced lung injury.
Authors
- Pengdou Zheng
- Fengqin Zhang (ORCID: https://orcid.org/0000-0001-9479-2456)
- Huiguo Liu (ORCID: https://orcid.org/0000-0002-9722-833X)
- Xiaoyan Zhu (ORCID: https://orcid.org/0000-0002-7998-6444)
- Guisha Zi
- Lingling Wang (ORCID: https://orcid.org/0009-0002-7086-8924)
- Wei Liu (ORCID: https://orcid.org/0000-0001-6435-6696)
- Lixiang Chen (ORCID: https://orcid.org/0000-0001-7785-2496)
- Ling Zhou (ORCID: https://orcid.org/0000-0003-1812-4127)
- Zhenyu Mao
Institutions
- Wuhan Pulmonary Hospital (CN)
- Tongji Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s12931-025-03370-y
- Citations
- 1
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52