MRI study on hippocampal subfield volume loss and abnormal functional connectivity in patients with diabetic retinopathy
Patients with diabetic retinopathy (DR) demonstrate structural alterations in hippocampal subfields and widespread functional dysconnectivity across the brain. Notably, the strength of functional connectivity between the hippocampus and the visual cortex was significantly and positively correlated with cognitive function. This study provides neuroimaging evidence supporting the mechanisms underlying central nervous system complications in DR, suggesting that hippocampal subfield volumes and specific functional connectivity patterns hold potential as neuroimaging biomarkers for early intervention.
Authors
- Weidong Ji (ORCID: https://orcid.org/0000-0002-9002-9362)
- Zhijun Zhou (ORCID: https://orcid.org/0000-0002-2549-6589)
- Ning Wang (ORCID: https://orcid.org/0000-0003-2478-0403)
- Xiujuan Chen (ORCID: https://orcid.org/0000-0003-1040-9937)
- Ji Zhang (ORCID: https://orcid.org/0000-0003-0963-1629)
- Liang He (ORCID: https://orcid.org/0000-0003-4443-5623)
- Jianguo Xia (ORCID: https://orcid.org/0000-0003-0242-1274)
- Weizhong Tian (ORCID: https://orcid.org/0000-0002-5589-3235)
- Yaqi Song (ORCID: https://orcid.org/0009-0003-2892-6729)
Institutions
- Nantong University (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- BMC Medical Imaging
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s12880-025-01979-5
- Primary Topic
- Neurological and metabolic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province