IFITM3-MET interaction drives osimertinib resistance through AKT pathway activation in EGFR-mutant non–small cell lung cancer
Our findings reveal that upregulation of IFITM3 driven by TME cytokines represents a previously unrecognized mechanism of osimertinib resistance, and they suggest that targeting of the IFITM3-MET axis may improve EGFR-TKI treatment outcome for EGFR-mutant NSCLC.
Authors
- Hirono Tsutsumi
- Shun Mizusaki
- Takayuki Nakanishi (ORCID: https://orcid.org/0000-0002-5560-6267)
- Daisuke Shibahara (ORCID: https://orcid.org/0000-0001-9540-7695)
- Ritsu Ibusuki
- Mikiko Hashisako (ORCID: https://orcid.org/0000-0001-5245-7342)
- Yui Miyazaki
- Atsushi Shimauchi
- Eiji Iwama (ORCID: https://orcid.org/0000-0001-8252-290X)
- Yuko Tsuchiya‐Kawano
- Kohei Otsubo (ORCID: https://orcid.org/0000-0002-9476-8840)
- Yoshinao Oda (ORCID: https://orcid.org/0000-0001-9636-1182)
- Yu Inutsuka
- Yuichiro Koga
- Noriaki Nakagaki
- Taishi Harada (ORCID: https://orcid.org/0000-0002-5145-9036)
- Kentaro Tanaka (ORCID: https://orcid.org/0000-0003-4602-4465)
- Satoshi Nakamura (ORCID: https://orcid.org/0000-0002-9198-8506)
- Shinichi Kimura (ORCID: https://orcid.org/0000-0002-2154-6569)
- Hiromu Kawano
- Isamu Okamoto
- Yasuto Yoneshima
- Shun Mashimoto
Institutions
- Kagoshima University (JP)
- Kyushu University (JP)
- St Mary's Hospital (JP)
- Japanese Red Cross Fukuoka Hospital (JP)
- Kyushu Hospital (JP)
- Kitakyushu Municipal Medical Center (JP)
- Fukuoka Higashi Medical Center (JP)
- Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers (JP)
- Saiseikai Fukuoka General Hospital (JP)
- Nippon Steel Yawata Memorial Hospital (JP)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s12943-025-02493-6
- Citations
- 3
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 4.56