Enrichment of Germline Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Pathogenic Variants in Patients With Solid Tumors: Evidence for Increased Cancer Risk
The overall prevalence of CFTR PVs in people with solid tumors was higher than expected. These results suggest that carriers of CFTR PV may benefit from enhanced cancer screening.
Authors
- James E. Slaven (ORCID: https://orcid.org/0000-0002-6744-3821)
- Cynthia D. Brown (ORCID: https://orcid.org/0000-0003-4057-0561)
- Leigh Anne Stout (ORCID: https://orcid.org/0000-0002-6584-1818)
- Todd C. Skaar (ORCID: https://orcid.org/0000-0002-3849-374X)
- Tyler Shugg (ORCID: https://orcid.org/0000-0002-5784-3565)
- Nick Powell (ORCID: https://orcid.org/0000-0003-3231-6950)
- Steven M. Bray (ORCID: https://orcid.org/0000-0002-0854-8121)
- Katherine A. Gallaway (ORCID: https://orcid.org/0000-0001-9568-6583)
- Emma M. Tillman (ORCID: https://orcid.org/0000-0001-8019-9811)
- Abi Colwell (ORCID: https://orcid.org/0009-0002-3804-9267)
Institutions
- Fountain University (NG)
- Indiana University Health (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Pediatric Pulmonology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/ppul.71360
- Citations
- 1
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Cancer Institute