Application of the Lancet Commission Criteria for the Diagnosis of Obesity to a Clinical Trials Population: The <scp>LEAP</scp> Trial
Among clinical trial participants eligible for obesity pharmacotherapy, 19.5% were classified as having no/pre-clinical obesity using the Lancet criteria. Applying the criteria was complicated in a well-resourced trial setting, which suggests potential challenges in implementing these guidelines in real-world practice.
Authors
- Kathleen Ruddiman (ORCID: https://orcid.org/0009-0005-5721-1874)
- Stephanie Ann Hooker (ORCID: https://orcid.org/0000-0003-4222-7046)
- Byron C. Jaeger (ORCID: https://orcid.org/0000-0001-7399-2299)
- Courtney Simmons (ORCID: https://orcid.org/0000-0002-3613-2377)
- Deborah B. Horn (ORCID: https://orcid.org/0000-0003-3493-9609)
- Kimberly A. Gudzune (ORCID: https://orcid.org/0000-0002-7782-1769)
- Caroline Blackwell Young
- Kristina H. Lewis (ORCID: https://orcid.org/0000-0002-4921-7230)
- Faith Anne N. Heeren (ORCID: https://orcid.org/0000-0002-6819-8258)
- Katy W. Martin‐Fernandez (ORCID: https://orcid.org/0000-0002-1879-3091)
- Brian N. White (ORCID: https://orcid.org/0009-0008-9742-9191)
- Jamy D. Ard (ORCID: https://orcid.org/0000-0002-1643-6795)
- Nicholas M. Pajewski
Institutions
- Atrium Health Wake Forest Baptist (US)
- University of Minnesota (US)
- Obesity Medicine Association (US)
- The University of Texas Health Science Center (US)
- Wake Forest University (US)
- HealthPartners (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Obesity
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1002/oby.70070
- Citations
- 1
- Primary Topic
- Pharmacology and Obesity Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- American Diabetes Association
- Amgen
- Eli Lilly and Company
- AstraZeneca
- Vanderbilt University
- Wake Forest University
- Johns Hopkins University
- Regeneron Pharmaceuticals
- WW International
- UnitedHealth Group
- Novo Nordisk
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Center for Advancing Translational Sciences