Plasma proteomics uncovers divergent molecular signatures in ischemic stroke and intracerebral hemorrhage
This study reveals a robust plasma proteomic signature distinguishing IS from ICH within hours of onset. These results lay the groundwork for scalable, blood-based diagnostics to guide early stroke management when imaging is delayed or unavailable.
Authors
- Tomás Segura (ORCID: https://orcid.org/0000-0003-3625-0987)
- Xabier Urra (ORCID: https://orcid.org/0000-0002-4763-5252)
- David Núñez-Jurado (ORCID: https://orcid.org/0000-0002-0360-5625)
- Gemma Serrano‐Heras (ORCID: https://orcid.org/0000-0001-9368-4832)
- Jerzy Krupiński (ORCID: https://orcid.org/0000-0002-5136-8898)
- Elena Muiño-Acuña
- Laia Llucià‐Carol (ORCID: https://orcid.org/0000-0002-7732-0665)
- Isabel Fernández‐Pérez (ORCID: https://orcid.org/0000-0002-9949-1393)
- Carmen del Río (ORCID: https://orcid.org/0000-0003-2332-2216)
- Marina Guasch‐Jiménez (ORCID: https://orcid.org/0000-0001-6024-8348)
- Joan Martí‐Fàbregas (ORCID: https://orcid.org/0000-0001-9229-8649)
- Garbiñe Ezcurra‐Díaz (ORCID: https://orcid.org/0000-0002-9511-3117)
- Natàlia Cullell (ORCID: https://orcid.org/0000-0001-5118-1014)
- Alejandro Fernández-Vega (ORCID: https://orcid.org/0000-0002-1141-1644)
- Mar Castellanos (ORCID: https://orcid.org/0000-0003-3116-1352)
- Israel Fernández‐Cadenas (ORCID: https://orcid.org/0000-0003-4821-2363)
- Sílvia Tur (ORCID: https://orcid.org/0000-0001-6995-5516)
- Cristòfol Vives-Bauzá (ORCID: https://orcid.org/0000-0001-5735-8335)
- Lourdes Arias-Salazar (ORCID: https://orcid.org/0009-0008-3331-3069)
- Anna Peñalba (ORCID: https://orcid.org/0000-0002-0241-2602)
- Joan Montaner (ORCID: https://orcid.org/0000-0001-9796-2422)
- Marimar Freijo-Guerrero
- Jordi Jiménez‐Conde
Institutions
- Universidade da Coruña (ES)
- Universitat Autònoma de Barcelona (ES)
- Hospital de Sant Pau (ES)
- BioCruces Health research Institute (ES)
- Hospital Universitario Virgen Macarena (ES)
- University Hospital Mútua de Terrassa (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Hospital Del Mar (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Hospital General Universitario de Albacete (ES)
- Hospital Universitario Son Espases (ES)
- Complejo Hospitalario Universitario de Albacete (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- Biomarker Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s40364-025-00848-1
- Citations
- 1
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- European Commission
- Instituto de Salud Carlos III