Activated Peripheral CD8 + T Lymphocytes Inhibit the Proliferation of Hippocampal Neural Stem Cells via the IFN‐γ/JAK/STAT Signaling Pathway
These results demonstrated that activated peripheral CD8 + T lymphocytes can indirectly inhibit the proliferation of hippocampal NSCs by secreting IFN-γ and subsequently activating the JAK/STAT signaling pathway in NSCs. Our study may help to better elucidate the regulatory role of neuroinflammation in hippocampal neurogenesis, especially in some pathological states.
Authors
- Zhaolan Feng (ORCID: https://orcid.org/0009-0004-3104-2331)
- Guicheng Wang (ORCID: https://orcid.org/0009-0001-0257-8944)
- Gongming Wang
- Chengyi Liu (ORCID: https://orcid.org/0000-0002-8851-3104)
- Shiyu Hao (ORCID: https://orcid.org/0009-0001-8201-2632)
- Yingxue He (ORCID: https://orcid.org/0009-0005-6793-4355)
- Yanjing Guo (ORCID: https://orcid.org/0009-0005-5629-302X)
- Q.-W Zhang
- Xiaobin Sun (ORCID: https://orcid.org/0009-0009-7442-6876)
- Xiaowei Li (ORCID: https://orcid.org/0000-0001-9097-6856)
Institutions
- Shandong Provincial Hospital (CN)
- Taian City Central Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/iid3.70287
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China