Characterization of microbiota dysbiosis in papillary thyroid carcinoma and benign thyroid nodules: low abundance of intestinal butyrate-producing bacteria
This study demonstrates that dysbiosis linked to thyroid nodules is marked by a substantial decline in intestinal butyrate-producing and butyrate-promoting taxa. Future work to confirm these results should include shotgun metagenomic sequencing paired with quantitative analyses of gene abundance and expression to fully ascertain the functional implications.
Authors
- Zhigang Ren (ORCID: https://orcid.org/0000-0003-0798-3444)
- Liangan Chen (ORCID: https://orcid.org/0000-0002-1829-3134)
- Haiyan Shi (ORCID: https://orcid.org/0000-0002-7085-5413)
- Changwen Wang (ORCID: https://orcid.org/0000-0002-8398-9445)
- Shusen Zheng (ORCID: https://orcid.org/0000-0003-1459-8261)
- Fuqiang Li (ORCID: https://orcid.org/0000-0002-2085-1457)
- Jun Pan (ORCID: https://orcid.org/0000-0003-3230-9136)
- Haifeng Lu (ORCID: https://orcid.org/0000-0003-2886-5615)
- Jinyan Huang (ORCID: https://orcid.org/0000-0002-8053-0209)
- Hua Zhang (ORCID: https://orcid.org/0000-0001-7333-9548)
- Danyang Zhao (ORCID: https://orcid.org/0000-0002-6466-3378)
- Yijun Wu
- Yanfei Chen
Institutions
- First Affiliated Hospital of Zhengzhou University (CN)
- National Center for Infectious Diseases (US)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s12866-025-04427-0
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Zhengzhou University
- Zhejiang University
- National Key Research and Development Program of China