Spontaneous and Radiation-induced Mammary and Thyroid Tumorigenesis in LEW and (SD×COP)F <sub>1</sub> <i>Brca1</i> <sup>L63X/+</sup> Rats
<i>Brca1</i> <sup>L63X/+</sup> rats on the LEW and (SD×COP)F<sub>1</sub> backgrounds did not recapitulate the human breast carcinogenesis phenotype. Notably, our findings suggest that a germline mutation in <i>Brca1</i> increases the prevalence of spontaneous thyroid tumors.
Authors
- Masaru Takabatake (ORCID: https://orcid.org/0000-0002-1484-6627)
- Kazuhiro Daino (ORCID: https://orcid.org/0000-0002-2711-4046)
- Kazuma Nagata (ORCID: https://orcid.org/0000-0001-9980-2086)
- Yuzuki Nakamura
- Shizuko Kakinuma (ORCID: https://orcid.org/0000-0001-9635-8813)
- Tomoji Mashimo (ORCID: https://orcid.org/0000-0001-7543-7301)
- Tatsuhiko Imaoka (ORCID: https://orcid.org/0000-0003-1507-585X)
- Toshiaki Kokubo (ORCID: https://orcid.org/0000-0003-2837-5448)
- Kazumasa Inoue (ORCID: https://orcid.org/0000-0003-1292-6364)
- Mayumi Nishimura
- YUKIKO NISHIMURA-YANO
Institutions
- Japan Society for the Promotion of Science (JP)
- Institute for Environmental Sciences (JP)
- National Institutes for Quantum Science and Technology (JP)
- Tokyo Metropolitan University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.21873/anticanres.17834
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00