c-MYC Protein Expression Patterns in Laryngeal-Hypopharyngeal Squamous Cell Carcinomas
c-MYC overexpression is a common feature in L-HPSCCs, mainly due to <i>c-MYC</i> oncogene overactivation. Increased levels of nuclear and diffuse cytoplasmic c-MYC protein are associated with aggressive phenotypes in patients with L-HPSCCs. Given the emerging interest in oncogene-targeted therapies in modern oncology, identifying patients with distinct <i>c-MYC</i> genetic, epigenetic, and proteomic signatures represents a promising strategy for personalized treatment approaches.
Authors
- Nikolaos Poulianitis
- GEORGE PAPANASTASIOU
- Dimitrios Tsounis
- Aristeidis Chrysovergis (ORCID: https://orcid.org/0000-0002-6708-2210)
- Dimitrios Roukas (ORCID: https://orcid.org/0000-0002-5207-2765)
- Sotirios Papouliakos (ORCID: https://orcid.org/0000-0001-6164-7279)
- Dimitrios Rigopoulos (ORCID: https://orcid.org/0000-0002-4841-7484)
- Andreas C. Lazaris
- Efthymios Kyrodimos (ORCID: https://orcid.org/0000-0001-5236-7961)
- PAVLOS PANTOS
- Evangelos Tsiambas (ORCID: https://orcid.org/0000-0001-5541-2465)
- Vasileios Papanikolaou (ORCID: https://orcid.org/0000-0002-9800-3650)
- Nikolaos Kavantzas
Institutions
- University of Ioannina (GR)
- National and Kapodistrian University of Athens (GR)
- General Hospital of Athens G. Genimatas (GR)
- NIMTS Hospital (GR)
- General Hospital of Athens Elpis (GR)
- Athens Naval & Veterans Hospital (GR)
- Hippocration General Hospital (GR)
- Sotiria General Hospital (GR)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.21873/anticanres.17838
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00