Very Rapid Eradication of a Large Squamous-Cell Carcinoma of the Head and Neck Treated With First-line Combination Chemotherapy, a Low-methionine Diet, and Oral Recombinant Methioninase
The combination of first-line chemotherapy, a low-methionine diet, and o-rMETase rapidly eradicated a very large HNSCC. The present results suggest this combination should be further tested, including clinical trials, as the regimen is highly effective in the present case and can possibly avoid disfiguring surgery and harmful radiation.
Authors
- Shinji Miwa (ORCID: https://orcid.org/0000-0002-5962-8287)
- SHUKUAN LI
- Byung Mo Kang (ORCID: https://orcid.org/0000-0003-0900-094X)
- Yohei Asano (ORCID: https://orcid.org/0000-0002-8777-6076)
- Katsuhiro Hayashi (ORCID: https://orcid.org/0000-0001-8665-2154)
- Norio Yamamoto (ORCID: https://orcid.org/0000-0002-7250-625X)
- Robert M. Hoffman (ORCID: https://orcid.org/0000-0002-0049-0041)
- KOHEI MIZUTA
- Satoru Demura
- HIROAKI KIMURA
- Takashi Higuchi (ORCID: https://orcid.org/0000-0003-3281-4669)
- Kentaro Igarashi (ORCID: https://orcid.org/0000-0003-2278-1736)
- Sei Morinaga (ORCID: https://orcid.org/0000-0003-2961-9432)
- Jin-Soo Kim (ORCID: https://orcid.org/0000-0002-1847-3741)
- Hiroyuki Tsuchiya (ORCID: https://orcid.org/0000-0002-2144-8272)
- Qinghong Han
- YUTA MIYASHI
Institutions
- Kanazawa University (JP)
- University of California San Diego (US)
- AntiCancer (United States) (US)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.21873/anticanres.17862
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00