Simultaneous Targeting of Multiple Hallmarks of Cancer With Recombinant Methioninase, Rapamycin and Chloroquine Is Specific and Synergistic to MiaPaCa-2 Pancreatic-Cancer Cells in Contrast to Hs-27 Normal Fibroblasts
The combination of rMETase, rapamycin and chloroquine had highly synergistic and selective efficacy against PDAC cells <i>in vitro</i> compared to normal cells, supporting its potential as a precision-targeted metabolic clinical therapy for pancreatic cancer.
Authors
- Michael Bouvet (ORCID: https://orcid.org/0000-0002-0086-2159)
- SHUKUAN LI
- Byung Mo Kang (ORCID: https://orcid.org/0000-0003-0900-094X)
- Yohei Asano (ORCID: https://orcid.org/0000-0002-8777-6076)
- KOHEI MIZUTA
- Jin‐Soo Kim (ORCID: https://orcid.org/0000-0001-8217-5071)
- Robert M. Hoffman
- Qinghong Han
- YUTA MIYASHI
Institutions
- Chungnam National University (KR)
- University of California San Diego (US)
- AntiCancer (United States) (US)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.21873/anticanres.17825
- Citations
- 1
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.23