Triple Combination of Recombinant Methioninase and the Anti-parasitic Drugs Ivermectin, and Chloroquine Selectively Eradicates Pancreatic Cancer Cells While Sparing Normal Fibroblasts
The combination of rMETase, ivermectin, and chloroquine exhibited a selective cytotoxic synergy against pancreatic-cancer cells while sparing normal fibroblasts. Furthermore, the order of treatment may also affect efficacy. This triple combination treatment may offer a novel and effective first-line therapeutic approach for pancreatic cancer.
Authors
- Shinji Miwa (ORCID: https://orcid.org/0000-0002-5962-8287)
- SHUKUAN LI
- Byung Mo Kang (ORCID: https://orcid.org/0000-0003-0900-094X)
- Yohei Asano (ORCID: https://orcid.org/0000-0002-8777-6076)
- Katsuhiro Hayashi (ORCID: https://orcid.org/0000-0001-8665-2154)
- Norio Yamamoto (ORCID: https://orcid.org/0000-0002-7250-625X)
- Takashi Higuchi (ORCID: https://orcid.org/0000-0003-2896-4939)
- Hiroyuki Tsuchiya (ORCID: https://orcid.org/0000-0003-0730-7921)
- KOHEI MIZUTA
- Satoru Demura
- Kentaro Igarashi (ORCID: https://orcid.org/0000-0003-2278-1736)
- Sei Morinaga (ORCID: https://orcid.org/0000-0003-2961-9432)
- Jin-Soo Kim (ORCID: https://orcid.org/0000-0002-1847-3741)
- Hiroaki Kimura (ORCID: https://orcid.org/0000-0003-2145-8726)
- Robert M. Hoffman
- Qinghong Han
- YUTA MIYASHI
Institutions
- Kanazawa University (JP)
- University of California San Diego (US)
- AntiCancer (United States) (US)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.21873/anticanres.17828
- Citations
- 1
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.23