Efficient Inhibition of FOXM1 Expression and Viability of High-grade Meningioma Cells by Domatinostat-mediated Dual Targeting of HDAC1 and HDAC2
Simultaneous inhibition of the class I HDACs, HDAC1 and HDAC2, reduced FOXM1 expression and suppressed cell proliferation in high-grade meningiomas. Furthermore, the class I HDAC inhibitor domatinostat inhibited FOXM1 expression and cell proliferation in high-grade meningioma cells within a concentration range that was not toxic to normal cell lines. These results suggest the potential of domatinostat as a therapeutic option for the treatment of high-grade meningiomas, which are often difficult to manage clinically.
Authors
- Keita Togashi
- Yurika Nakagawa-Saito (ORCID: https://orcid.org/0000-0002-9904-8842)
- Asuka Sugai
- Chifumi Kitanaka
- Yasufumi Ito
- Kazuki Nakamura (ORCID: https://orcid.org/0000-0002-6322-762X)
- Yukihiko Sonoda (ORCID: https://orcid.org/0000-0001-7651-1374)
- Masashi Okada (ORCID: https://orcid.org/0000-0002-6333-6076)
- Yuta Mitobe (ORCID: https://orcid.org/0009-0004-6963-6004)
- Senri Takenouchi
- Shuhei Suzuki (ORCID: https://orcid.org/0000-0003-1975-0146)
Institutions
- Yamagata University (JP)
- Yamagata Prefectural Shinjo Hospital (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.21873/anticanres.17833
- Citations
- 1
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81