Clearance of <i>TP53</i> Mutations in ctDNA Reflects Therapeutic Response in Advanced Pancreatic Cancer Patients
Dynamic changes in ctDNA, particularly the disappearance of <i>TP53</i> mutations, serve as a sensitive biomarker for chemotherapy response in advanced PDAC, even when traditional markers like CA 19-9 are unreliable. Longitudinal ctDNA profiling offers a promising approach to guide early treatment evaluation and may inform therapeutic strategies targeting resistant subclones.
Authors
- T.Y. Lee
- Yifei Yun
- Young Hyuck Cheon
- Sang Hoon Lee (ORCID: https://orcid.org/0000-0002-7706-5318)
- Dong Wook Kim (ORCID: https://orcid.org/0000-0002-5819-9783)
- Seoyoung Kim
- Jong-Hwan Kim (ORCID: https://orcid.org/0000-0001-6699-072X)
Institutions
- Konkuk University (KR)
- Gumi University (KR)
- Konkuk University Medical Center (KR)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.21873/anticanres.17836
- Citations
- 1
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.05