The MDM4 Inhibitor CEP-1347 Activates Wild-type p53 in Ovarian Clear Cell Carcinoma Cells and Potently Inhibits their Growth
The present results suggest the potential of targeting MDM4 with CEP-1347 as a therapeutic approach for the treatment of OCCC with wild-type p53.
Authors
- Keita Togashi
- Manabu Seino (ORCID: https://orcid.org/0000-0002-7511-5190)
- Shuhei Suzuki (ORCID: https://orcid.org/0009-0003-8108-3230)
- Yurika Nakagawa-Saito (ORCID: https://orcid.org/0000-0002-9904-8842)
- MASASHI OKADA
- Asuka Sugai
- Chifumi Kitanaka
- Yasufumi Ito
- Kazuki Nakamura (ORCID: https://orcid.org/0000-0002-6322-762X)
- Satoru Nagase (ORCID: https://orcid.org/0000-0001-5212-1128)
- Tsuyoshi Ohta (ORCID: https://orcid.org/0000-0002-4819-4233)
- Seiji Takenouchi
Institutions
- Yamagata University (JP)
- Yamagata Prefectural Shinjo Hospital (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.21873/anticanres.17835
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00