Magnolol Traverses the Blood-brain Barrier and Enhances Temozolomide-induced Intrinsic Apoptosis of Glioblastoma Cells <i>via</i> a p53 Redox Signaling Mechanism
Magnolol traverses the CEC barrier and amplifies TMZ-induced apoptosis in glioblastoma cells through an intrinsic ROS-p53-caspase signaling cascade. Given its safety toward normal astrocytes and endothelial cells, magnolol represents a promising adjuvant strategy to improve TMZ-based therapy, potentially mitigating drug resistance and adverse effects in GBM treatment.
Authors
- JUI-TAI CHEN
- Edwin Chen (ORCID: https://orcid.org/0000-0003-0742-9734)
- Gang Wu (ORCID: https://orcid.org/0000-0001-8941-2500)
- Ruei‐Ming Chen (ORCID: https://orcid.org/0000-0002-5728-0571)
- SHING-HWA LIU
Institutions
- University of British Columbia (CA)
- National Taiwan University (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.21873/anticanres.17842
- Primary Topic
- Magnolia and Illicium research
- Type
- article
- Field-Weighted Citation Impact
- 0.00