MGMT Promoter Methylation in Glioblastoma Stem Cells: Stability During Differentiation and Comparison With Surgically-resected Tumors
MGMT promoter methylation status in glioblastoma stem cells remained unchanged during differentiation and was comparable to that in surgically resected tumors. As temozolomide is presumed to be ineffective against glioblastoma stem cells with unmethylated MGMT promoters, MGMT blockade may be a beneficial therapeutic strategy.
Authors
- SHINICHIRO MOTOHASHI
- Masayoshi Kobayashi (ORCID: https://orcid.org/0000-0002-7133-1785)
- Yoshinori Higuchi (ORCID: https://orcid.org/0000-0001-5689-3416)
- Masaki Yoshioka (ORCID: https://orcid.org/0009-0009-9672-1374)
- Yasuo Iwadate (ORCID: https://orcid.org/0000-0002-5159-6049)
- SHUNSEI NOGUCHI
Institutions
- Chiba University (JP)
- Teikyo University Chiba Medical Center (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.21873/anticanres.17839
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63