Senolytic Elimination of Senescent Ovarian Clear Cell Carcinoma Cells Induced by CEP-1347 With the BH3 Mimetic Navitoclax
CEP-1347 induced cellular senescence in OCCC cells with wild-type <i>TP53</i>. The combination of CEP-1347 with senolytics, such as navitoclax, represents a rational strategy to ensure the selective elimination of senescent OCCC cells and enhance therapeutic efficacy.
Authors
- Keita Togashi
- Manabu Seino (ORCID: https://orcid.org/0000-0002-7511-5190)
- Yurika Nakagawa-Saito (ORCID: https://orcid.org/0000-0002-9904-8842)
- MASASHI OKADA
- Asuka Sugai
- Chifumi Kitanaka
- Yasufumi Ito
- Kazuki Nakamura (ORCID: https://orcid.org/0000-0002-6322-762X)
- Satoru Nagase (ORCID: https://orcid.org/0000-0001-5212-1128)
- Tsuyoshi Ohta (ORCID: https://orcid.org/0000-0002-4819-4233)
- Yuta Mitobe (ORCID: https://orcid.org/0009-0004-6963-6004)
- Seiji Takenouchi
- Shuhei Suzuki (ORCID: https://orcid.org/0000-0003-1975-0146)
Institutions
- Yamagata University (JP)
- Yamagata Prefectural Shinjo Hospital (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.21873/anticanres.17832
- Citations
- 1
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.05