HDAC5 Inhibition as a Therapeutic Strategy for Titin Deficiency-Induced Cardiac Remodeling: Insights from Human iPSC Models
Our findings identify HDAC5 as a key epigenetic regulator of maladaptive gene expression in <i>TTN</i> deficiency. Although the precise mechanisms remain to be clarified, the ability of pharmacological HDAC5 inhibition with TMP-195 to reverse <i>TTN</i>-deficiency-induced gene dysregulation highlights its promising translational potential for <i>TTN</i>-related cardiomyopathies.
Authors
- Arif Ul Hasan (ORCID: https://orcid.org/0000-0002-6491-347X)
- Sachiko Sato (ORCID: https://orcid.org/0000-0002-5960-1703)
- Yukiko Kondo
- Eiichi Taira (ORCID: https://orcid.org/0000-0001-5741-3058)
- Mami Obara
Institutions
- Iwate Medical University (JP)
Publication Details
- Journal
- Medicines
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3390/medicines12040026
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00