Synthesis, Characterization, and Evaluation of the Antibacterial Activity of Some Novel Thiazolo- [1,2,4] Triazolo [1,5-a] Pyridine Derivatives

A novel four-step scientific protocol has been reported for the synthesis of thiazolo- [1,2,4] triazolo[1,5-a] pyridine and its derivatives (6a-c) as target moieties in good overall yields by using 1-(2-(Trifluoromethyl)-5-methylthiazol-4- yl) ethanone (1) as starting compound. The IR, PMR, Mass spectral data, and elemental analysis validated the chemical structures of all the intermediates and products. Furthermore, the newly synthesised intermediates and final derivatives were screened for their antibacterial activity against different bacterial strains, and it was found that a few of them exhibited noteworthy antibacterial activity with varying degrees of disparity.r academic research and practical applications.