Identifying the anti-infection NK and T cell subgroups in preterm newborns with sepsis using single-cell RNA-seq analysis
The scRNA-seq analysis of preterm infants with late-onset sepsis revealed enrichment of T and NK cell subsets with heightened regulon activity and antibacterial/oxidative stress programs, indicating potential association with the host infection response.
Authors
- Ji Liu (ORCID: https://orcid.org/0000-0002-6769-3425)
- Weihong Zhang (ORCID: https://orcid.org/0000-0001-5495-158X)
- Rongrong Xu (ORCID: https://orcid.org/0000-0002-7365-7543)
- Jiawei Ma (ORCID: https://orcid.org/0000-0001-8779-0188)
- Shengquan Wang (ORCID: https://orcid.org/0000-0002-3841-7552)
- Jia Wu
- Anaerguli Maimaitituerxun
- Alima Aximu
Institutions
- Jiangnan University (CN)
- Second Military Medical University (CN)
- Wuxi Fourth People's Hospital (CN)
- County Hospital (GB)
- Jiangxi Provincial Children's Hospital (CN)
- Shanghai Pudong New Area Gongli Hospital (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s40001-025-03272-1
- Citations
- 1
- Primary Topic
- Neonatal and Maternal Infections
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Natural Science Foundation of Xinjiang