Dietary curcumin prevents hypercholesterolemia by inhibiting the transcriptional activity of SREBP-2 and HNF1α and reducing intestinal and hepatic NPC1L1 expression in high-fat diet-fed hamsters
Our findings indicate that curcumin prevents HFD-induced hypercholesterolemia by transcriptionally suppressing intestinal and hepatic NPC1L1 expression and cholesterol absorption via inhibition of SREBP-2 and HNF1α transcriptional activity. Our research provides evidence for curcumin as a potential nutraceutical for hypercholesterolemia treatment by regulating NPC1L1 and enterohepatic circulation metabolism of cholesterol.
Authors
- Jie Yang (ORCID: https://orcid.org/0000-0003-0069-667X)
- Dan Feng (ORCID: https://orcid.org/0000-0002-0311-8990)
- Ting Hong (ORCID: https://orcid.org/0000-0001-5737-8926)
- Xiaobing Chen (ORCID: https://orcid.org/0000-0001-9852-706X)
- Zhuo Cao (ORCID: https://orcid.org/0009-0003-9275-8141)
- Haiyan Mai (ORCID: https://orcid.org/0009-0007-7022-173X)
Institutions
- Sun Yat-sen University (CN)
- Key Laboratory of Guangdong Province (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Nutrition & Metabolism
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s12986-025-01031-x
- Citations
- 1
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- Chinese Nutrition Society
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province