Glycoprotein non-metastatic melanoma protein B is a biomarker of inflammation in individuals with Gaucher disease: relationship to clinico-pathological subtypes
Our findings indicate that the association of plasma gpNMB with liver cirrhosis, gammopathy and pulmonary disease in Gaucher disease warrants further investigation. Additionally, plasma gpNMB may serve as a supportive biomarker in the evaluation and clinical monitoring of residual disease activity. However, plasma gpNMB neither differentiated between the neuronopathic subtypes of Gaucher disease nor idiopathic Parkinson's disease.
Authors
- Kathy Page
- Kerri‐Lee Wallom (ORCID: https://orcid.org/0000-0002-2842-1275)
- Ellen Hertz (ORCID: https://orcid.org/0000-0002-0916-3557)
- Per Svenningsson (ORCID: https://orcid.org/0000-0001-6727-3802)
- Chong Yew Tan (ORCID: https://orcid.org/0000-0002-5540-8412)
- Daniëlle te Vruchte (ORCID: https://orcid.org/0000-0002-1709-1709)
- Sebile Kılavuz (ORCID: https://orcid.org/0000-0002-7527-2620)
- Andrea Sturchio (ORCID: https://orcid.org/0000-0002-1067-2834)
- Panagiota Tsitsi (ORCID: https://orcid.org/0000-0003-3790-0398)
- Frances M. Platt (ORCID: https://orcid.org/0000-0001-7614-0403)
- Timothy M. Cox (ORCID: https://orcid.org/0000-0002-4951-9941)
- Aimée Donald (ORCID: https://orcid.org/0000-0002-2623-5233)
- Mattias Andréasson (ORCID: https://orcid.org/0000-0003-3472-3947)
- Simona D’Amore (ORCID: https://orcid.org/0000-0002-5432-8808)
- Ioanna Markak
- Ana Catarina Gomes Almeida Augusto Caçote
Institutions
- Royal Free London NHS Foundation Trust (GB)
- University of Cambridge (GB)
- Manchester Academic Health Science Centre (GB)
- Karolinska Institutet (SE)
- University of Manchester (GB)
- University of Oxford (GB)
- University of Bari Aldo Moro (IT)
- Marmara University (TR)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s13023-025-04054-y
- Citations
- 1
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- King's College London
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- Medical Research Council