CT-derived brain volumes and plasma p-Tau217 for risk stratification of amyloid positivity in early-stage Alzheimer’s disease
This CT-based, two-stage approach is a cost-effective, scalable alternative to MRI-based strategies, leveraging routine CT and selective p-Tau217 testing to enhance early AD detection and optimize resource utilization in clinical practice.
Authors
- Jun Pyo Kim (ORCID: https://orcid.org/0000-0003-4376-3107)
- Duk Lyul Na (ORCID: https://orcid.org/0000-0002-0098-7592)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Min-Young Chun
- Fernando González‐Ortiz (ORCID: https://orcid.org/0000-0001-7897-9456)
- Kian Yew Lim
- Kichang Kwak (ORCID: https://orcid.org/0000-0003-4542-0001)
- Seongbeom Park (ORCID: https://orcid.org/0000-0002-0759-6826)
- Hyemin Jang (ORCID: https://orcid.org/0000-0003-3152-1274)
- Sang Won Seo (ORCID: https://orcid.org/0000-0002-8747-0122)
- Jihwan Yun (ORCID: https://orcid.org/0000-0002-2436-4947)
- Sung Hoon Kang (ORCID: https://orcid.org/0000-0002-2481-0302)
- Hyun‐Sik Kang (ORCID: https://orcid.org/0000-0002-8611-1873)
- Eun‐Joo Kim (ORCID: https://orcid.org/0000-0002-8460-1377)
- Hee‐Jin Kim (ORCID: https://orcid.org/0000-0003-3741-4613)
- Daeun Shin (ORCID: https://orcid.org/0000-0003-4834-1026)
- Nicholas J. Ashton
- Michael Walter Weiner (ORCID: https://orcid.org/0000-0002-0144-1954)
- Henrik Zetterberg
- S.F. Yim (ORCID: https://orcid.org/0000-0002-9357-768X)
Institutions
- Jain University (IN)
- University of Science and Technology of China (CN)
- University of Wisconsin–Madison (US)
- University of California, San Francisco (US)
- King's College London (GB)
- Yonsei University (KR)
- Severance Hospital (KR)
- Korea University Medical Center (KR)
- Stavanger University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- University of California System (US)
- Centre for Mental Health (GB)
- Kyung Hee University (KR)
- Sorbonne Université (FR)
- Pusan National University Hospital (KR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Kyung Hee University Dental Hospital (KR)
- National Hospital for Neurology and Neurosurgery (GB)
- Institut du Cerveau (FR)
- University College London (GB)
- Sungkyunkwan University (KR)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s13195-025-01870-z
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- National Institute for Health and Care Research
- University College London
- European Commission
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Hjärnfonden
- Vetenskapsrådet
- Ministry of Science and ICT, South Korea
- UK Dementia Research Institute
- Samsung
- HORIZON EUROPE Framework Programme
- Korea National Institute of Health
- Institute for Information and Communications Technology Promotion