Systematic evaluation of porcine platelet lysate as a fetal bovine serum substitute: enhancing cell proliferation, maintaining differentiation potential, and ensuring immunophenotypic stability
pPL effectively supports the in vitro expansion of various cells, helps maintain the immunophenotypic stability of MSCs, and shows superiority in osteogenic differentiation. With its unique "proliferation-first, differentiation-controllable" advantage from a natural growth factor network, pPL offers a new approach for developing FBS substitutes.
Authors
- Shijie Meng
- Letian Shan (ORCID: https://orcid.org/0000-0003-4926-0527)
- Wenyue Hu (ORCID: https://orcid.org/0000-0002-4662-3727)
- Xiaotian Chen (ORCID: https://orcid.org/0000-0001-6112-0784)
- Qiang Yuan (ORCID: https://orcid.org/0000-0002-1450-7086)
- Li Zhou (ORCID: https://orcid.org/0000-0003-1083-0211)
- Siqing Chen (ORCID: https://orcid.org/0000-0001-8530-4174)
- Huiling Wu
Institutions
- Zhejiang Chinese Medical University (CN)
- Zhejiang Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s13287-025-04694-8
- Citations
- 1
- Primary Topic
- Periodontal Regeneration and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.84
Funders
- National Natural Science Foundation of China
- Zhejiang Chinese Medical University
- Natural Science Foundation of Zhejiang Province