Soluble CSF1R promotes microglial activation and amyloid clearance in alzheimer’s disease
These findings identify sCSF1R as a novel component of the neuroimmune signaling network in AD and highlight its dual potential as a CSF biomarker of beneficial microglial activation and a candidate therapeutic modulator of neuroinflammation and amyloid pathology.
Authors
- Kai Chen (ORCID: https://orcid.org/0000-0002-0891-3408)
- Lianshuai Zhang
- Guojun Bu (ORCID: https://orcid.org/0000-0003-3491-1016)
- Rebecca Zeng (ORCID: https://orcid.org/0000-0002-1186-4758)
- Xiao‐Fen Chen
Institutions
- Shenzhen University (CN)
- Xiamen University (CN)
- Hong Kong University of Science and Technology (HK)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s12974-025-03558-5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province