Metabolic dysfunction-associated fatty liver disease and the risk of gout: a UK Biobank prospective cohort study
MASLD independently associates with increased gout risk, persisting after comprehensive confounder adjustment. These findings underscore MASLD's potential role in gout pathogenesis and highlight the clinical relevance of targeted MASLD interventions for gout prevention. Mechanistic and causal investigations remain warranted.
Authors
- Xin Liu (ORCID: https://orcid.org/0000-0003-0727-5659)
- Qinghui Niu (ORCID: https://orcid.org/0009-0005-8158-7484)
- Qian Yu (ORCID: https://orcid.org/0000-0001-9774-9226)
- Hui Song
- Xiangjia Zhu (ORCID: https://orcid.org/0000-0001-6131-9582)
- Chang Li (ORCID: https://orcid.org/0000-0001-8019-3794)
- Yangang Wang (ORCID: https://orcid.org/0000-0001-8646-1403)
- Ying Chen (ORCID: https://orcid.org/0000-0001-6180-1600)
- Zibin Tian (ORCID: https://orcid.org/0000-0002-3050-0327)
- Yi Wang (ORCID: https://orcid.org/0000-0002-2633-2295)
Institutions
- Qingdao University (CN)
- Chinese University of Hong Kong (HK)
- Eye & ENT Hospital of Fudan University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Zigong First People's Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s40001-025-03298-5
- Citations
- 2
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- National Natural Science Foundation of China
- Jiangsu Development and Reform Commission
- Health Commission of Sichuan Province
- Sichuan Province Science and Technology Support Program