Endogenous Repair in Vanishing White Matter
Loss of glial cell functions in the cerebral white matter relates to irreversible degeneration, whereas preserved glial functions and valid inflammatory response in the pons coincide with spontaneous repair in vanishing white matter. Unraveling the cellular behavior underlying the potential for repair in the pons could pave the way to novel treatment strategies for this still incurable disease. ANN NEUROL 2026;99:737-747.
Authors
- Jodie H.K. Man (ORCID: https://orcid.org/0000-0002-2155-469X)
- Erik Nutma (ORCID: https://orcid.org/0000-0002-7332-1636)
- Marianna Bugiani (ORCID: https://orcid.org/0000-0001-7689-3042)
- Marjo S. van der Knaap (ORCID: https://orcid.org/0000-0001-8912-0954)
- Menno D. Stellingwerff (ORCID: https://orcid.org/0000-0001-8881-4989)
- Marjolein Breur (ORCID: https://orcid.org/0000-0002-8703-4494)
- Bonnie C. Plug
- Truus E. M. Abbink (ORCID: https://orcid.org/0000-0001-6932-0449)
Institutions
- Biomedical Primate Research Centre (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Cognitive Research (United States) (US)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1002/ana.78083
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00